Rudolphi was born in Stockholm to German parents. He was awarded his doctorate in 1795, from the University of Greifswald, where he was appointed Professor of Anatomy. He worked widely across the fields of botany, zoology,anatomy and physiology. He investigated the anatomy of nerves, carried out studies of plant growth and was an early champion of the view that the cell is the basic structural unit of plants. In 1804, Karl Rudolphi, along with J.H.F. Linkwere awarded the prize for "solving the problem of the nature of cells" by theKönigliche Societät der Wissenschaft (Royal Society of Science), Göttingen, for proving that cells had independent rather than common walls.
His first great publication was a study of parasitic worms, the "Enterozoorum Sive Vermium Intestinalium Historia Naturalis". This is the first publication to describe the Nematoda. His second, the "Synopsis cui accedunt mantissima duplex et indices locupletissima" was the first work to detail the life cycle of important nematode parasites of humans, such as Ascaris lumbricoides. (http://en.wikipedia.org/wiki/Karl_Rudolphi)